未完成

听说，这个blog不能操作啦。我要来试试。

offer来了，心也美啦，就是早啦，难决定啦

大话绿野仙踪

那个夜晚，小雪骤降，寒气逼人。我决定早些睡觉，于是，一个奇怪的梦姗然而至......

   我睁开睡眼，发现自己躺在一棵林桦树下。天空十分林朗，一轮宋阳洒下金黄的李靖辉，甚是张莉莉。我站起身来，感到很轻松。这时，一片新绿映入眼帘，让我目眩：四周是大片的孙霖，显得很张景，只有几只胡燕在枝头低唱；树下几只闵扬在嬉戏，还有许多叫不出名的花，有些刚刚张萌，有些已经庞湛了，散发着清香，一派生气勃勃的霍仲春。我简直不敢相信我的眼睛！

  我呆呆地站在那儿，欣赏着这春的美景，早已忘记了家中的罗东。不知过了多久，一阵李丰忽起，接着就是瓢泼唐宇。我真是不知所措，急忙躲到一棵大张松下避雨。那雨一直下到傍晚，我又饿又冷，我该怎么办？我在彷徨之中，忽见天上一巨大的周鹏落到我跟前，化作一白发道人。那道人道：我是屈玉昆、刘杨河、徐晶洞的王童真人。我来给你指点鲍向津。你顺着这条王璐直行，穿过一片许琳，便可找到人家了。他刚说完，便化为一缕祁嫣，消失的无影无踪。

 我按老道的话走了好久，天空已挂起一轮钮心悦，路上格外的杨宁。不久，我发现远处一片杨晚竹之中，有一道砖红的王强，我激动得阎磊直流，终于有救了！！！不一会儿，我找到了墙院的大门，这门包着一层马凯铁，十分坚硬，上面镶着几颗郭晶，闪着刘雪亮，甚是夺目；门上书三个大字：刘旭元。园中更是景色优美，如仙阁一般。接着，我被二个女仆带到大厅，厅中是些陈设。正中一面赵奇，上绘有田晓麟，看上去很武猛。左侧摆了几件乐器，孙勤、李守庆、宋铮应有尽有；右侧是些字画，分别写着张钧泰、盛宝善等吉祥的话。这时，主人出来和我见了面，并马上设下酒宴，真是张恺大方。我喝了5瓶蔡斌，还张哲大嘴吃肉，真是贪婪。最后，当我的胃李妲到绝对饱和的时候，我已“沉醉不知归路”了。

  曾经有一份友情摆在我面前，我们要好好珍惜喔！！！！！

（m曾经闲得无聊，写点废话；k今天闲得无聊，翻了出来，hohohohoho, merry xmas！）

愿每一年的这个时刻，都那么幸福快乐...

无论有什么不爽，回家烦恼都统统跑掉了，耶！

家，真好

>> together a lot of bits of chemistry and biology. I'm sorry that I

>> had to run right after class, but I had some child care duties.

最后引此paper的introduction--

Introduction

Protein glycosylation, or the covalent attachment of carbohydrates to nascent peptides, is a ubiquitous and extraordinarily complicated process that greatly expands the structural and functional potentials of secreted and cell surface proteins. The reaction occurs throughout the entire phylogenic spectrum, spanning from archaea to eukaryotes, and its abundance, structural diversity and chemical complexity exceeds all other types of co- and post-translational modifications combined. 1,2,3 Three natural protein glycosylation pathways are known, including N-linked glycosylation, O-linked glycosylation, and attachment of membrane proteins to glycosyl phosphatidyl-inositol (GPI) anchors. In the mid 1980s, evidences start to accumulate and prove the existence of additional “simple intracellular” glycosylation processes, involving dynamic monosccharides added to nuclear and cytoplasmic proteins serving as regulatory switches.4

In a recent analysis of nearly 75000 entries in the SWISS-PROT protein sequence data bank, Apweiler et al. predicted that more than half of all eukaryotic protein species are glycoproteins, 90% of which are likely to carry N-linked glycans with an average of 1.9 N-linked glycans per polypeptide chain.5 It has also been estimated that at least 0.5-1% of the transcribed human genome is devoted to the production of proteins involved in the synthesis, degradation, and function of glycoconjugates, underscoring the importance of glycosylation events to the cell.6 Indeed, many glycoproteins contain dense and complex arrays of oligosaccharides that assume a significant portion of the total molecular mass (up to 3kDa)7 and allow specific and differential intermolecular or intercellular interactions at multicellular or organismic levels. However, in many cases, the functions of protein-bound carbohydrates and their variations remain unclear or even shown to be trivial. Many enigmas remain to be solved in the biosynthesis, functions, and control of protein glycosylation, and the evolutionary significance for such a complicated protein modification process and its apparently wasteful biosynthetic strategy is curious.